Analysis of the Dissolution and Crystallization of Partly Immiscible Ternary Mixtures Using a Composite Sensor Array of In Situ ATR-FTIR, Laser Backscattering, and Imaging

The thermodynamic phase diagram of an agrochemical active ingredient (AI) in water and acetone was determined using array process analytical technology (PAT) tools equilibrium experiments. This ternary system found to separate into multiple liquid phases at certain temperatures concentrations (oiling out). Furthermore, agglomeration the solid particles observed specific conditions. Signals from laser backscattering, attenuated total reflection infrared spectroscopy, situ imaging were used study oiling out understand interactions among different how they affected dynamics dissolution crystallization AI. Characterizing partly immiscible mixtures is a challenging task due presence dispersed such as droplets, particles, agglomerates that are difficult discriminate traditional techniques. approach proposed here combines integrates signals complementary online measurements monitor complex systems.